SPIONs for Stem cell therapy! Check it out at
http://www.stemcellresearchnews.com/absolutenm/anmviewer.asp?a=2769&z=9
In a discovery that may help speed use of cell therapy, scientists report development of a way to deliver therapeutic human cells to diseased areas within the body using a simple magnetic effect.
Rawil Fakhrullin and colleagues from the Kazan State Medical University (Republic of Tatarstan) said that cell therapy aims to replace damaged or diseased cells in the human body with normal cells or stem cells. To do so, medical personnel need a way to target these cells to diseased organs or tissues.
So-called superparamagnetic iron oxide nanoparticles (SPIONs), attached to therapeutic cells, show promise. Magnetic devices could be used to move such cells to diseased areas of the body. But current ways of attaching SPIONs to therapeutic cells are difficult to use and may damage the therapeutic cells. So the researchers set out to develop a better process for attaching SPIONs to human cells.
They describe a new process for making “stabilized” SPIONs in the laboratory and successful attachment of these magnetic nanoparticles to the outside of human cells.
They found that the SPIONs were not toxic to cells, and they moved in response to a magnet.
“Our current results, as we believe, will inspire scientists to apply the simple and direct technique reported here in tissue engineering and cell-based therapies,” the researchers wrote.
Citation: “A Direct Technique for Magnetic Functionalization of Living Human Cells;” Maria R. Dzamukova, Rawil Fakhrullin et al.; Langmuir, 27 October 2011, 27 (23), pp 14386–14393, DOI: 10.1021/la203839v
Abstract: Click here.
Contact: Rawil Fakhrullin, +7-843-233-78-33,kazanbio@gmail.com
In a discovery that may help speed use of cell therapy, scientists report development of a way to deliver therapeutic human cells to diseased areas within the body using a simple magnetic effect.
Rawil Fakhrullin and colleagues from the Kazan State Medical University (Republic of Tatarstan) said that cell therapy aims to replace damaged or diseased cells in the human body with normal cells or stem cells. To do so, medical personnel need a way to target these cells to diseased organs or tissues.
So-called superparamagnetic iron oxide nanoparticles (SPIONs), attached to therapeutic cells, show promise. Magnetic devices could be used to move such cells to diseased areas of the body. But current ways of attaching SPIONs to therapeutic cells are difficult to use and may damage the therapeutic cells. So the researchers set out to develop a better process for attaching SPIONs to human cells.
They describe a new process for making “stabilized” SPIONs in the laboratory and successful attachment of these magnetic nanoparticles to the outside of human cells.
They found that the SPIONs were not toxic to cells, and they moved in response to a magnet.
“Our current results, as we believe, will inspire scientists to apply the simple and direct technique reported here in tissue engineering and cell-based therapies,” the researchers wrote.
Citation: “A Direct Technique for Magnetic Functionalization of Living Human Cells;” Maria R. Dzamukova, Rawil Fakhrullin et al.; Langmuir, 27 October 2011, 27 (23), pp 14386–14393, DOI: 10.1021/la203839v
Abstract: Click here.
Contact: Rawil Fakhrullin, +7-843-233-78-33,kazanbio@gmail.com
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