Just discovered the wonderful blog about the hot cell therapy topic! http://roosterbio.blogspot.com - there are lots of opinions on mesenchymal stem cell biology, clinical utility and other aspects. The most stunning thing about this blog is the courage for discussing the "uncomfortable" questions. These questions are intensively avoided because of some "anti-commercial" conclusions, but the resolving of such problems is extremely important for the development of safe and effective regenerative medicine.
Showing posts with label bone marrow. Show all posts
Showing posts with label bone marrow. Show all posts
1/13/2015
5/26/2012
Stem Cell Comics
Open publication - Free publishing
Beautiful educational comics about stem cells! ‘Hope Beyond Hype’ is a story about stem cell therapies from science discovery to working therapy.
4/16/2012
Cool Article About the History of Stem Cell Research!
That's wonderful! I thought about it lots of times!
Who really discovered stem cells?
Is it even possible that one scientific team all by themselves discovered something so ubiquitous as stem cells?
In theory “yes”, but after much historical research including this great historical article in Cell Stem Cell, I would argue that no one group really discovered stem cells.
Instead I believe the “discovery” of stem cells was an ongoing team effort over a period of many decades and there is much credit to go around.
Who gets the credit now according to most people now for “discovering” stem cells?
Canada rightly takes pride in the work of their scientists Drs. James Till and Ernset McCulloch, who did pioneering studies in hematopoietic stem cell research.
In Canada, Till and McCulloch are unambiguously called the world’s discoverers of stem cells. Period. No ambiguity.
But is that correct?
Nope.
12/27/2011
Stem Cells Can Kill Rare genetic Skin Disease
John E. Wagner and Jakub Tolar, in collaboration with researchers in Portland, Oregon, the United Kingdom, and Japan have for the first time used stem cells from bone marrow to repair the skin of patients with a fatal skin disease called recessive dystrophic epidermolysis bullosa, or RDEB.
This is the first time researchers have shown that bone marrow stem cells can home to the skin and upper gastrointestinal tract and alter the natural course of the disease.
"Whether stem cells from marrow could repair tissues other than itself has been quite controversial," said Wagner.
"But in 2007 we found a rare subpopulation of marrow stem cells that could repair the skin in laboratory models. This astounding finding compelled us to test these stem cells in humans. This has never been done before," Wagner added.
Tolar said: "This discovery is more unique and more remarkable than it may first soundbecause until now, bone marrow has only been used to replace diseased or damaged marrow – which makes sense.
"But what we have found is that stem cells contained in bone marrow can travel to sites of injured skin, leading to increased production of collagen which is deficient in patients with RDEB," Tolar added.
Epidermolysis bullosa (EB) is a rare, genetic skin disease that causes skin to blister and scrape off with the slightest friction or trauma. It affects the skin and lining of the mouth and esophagus. Previously, there was no treatment and no chance for cure.
In some countries, even euthanasia has been considered for newborns with the severest forms. If children with EB do not die of infection in their early life, many with the disease do not live beyond their 20s or 30s because they develop an aggressive form of skin cancer. While a few will live long term, the severest forms of EB are generally lethal.
"Bone marrow transplantation is one of the riskiest procedures in medicine, yet it is also one of the most successful. Patients who otherwise would have died from their disease can often now be cured. It''s a serious treatment for a serious disease," said Tolar. (ANI)
This is the first time researchers have shown that bone marrow stem cells can home to the skin and upper gastrointestinal tract and alter the natural course of the disease.
"Whether stem cells from marrow could repair tissues other than itself has been quite controversial," said Wagner.
"But in 2007 we found a rare subpopulation of marrow stem cells that could repair the skin in laboratory models. This astounding finding compelled us to test these stem cells in humans. This has never been done before," Wagner added.
Tolar said: "This discovery is more unique and more remarkable than it may first soundbecause until now, bone marrow has only been used to replace diseased or damaged marrow – which makes sense.
"But what we have found is that stem cells contained in bone marrow can travel to sites of injured skin, leading to increased production of collagen which is deficient in patients with RDEB," Tolar added.
Epidermolysis bullosa (EB) is a rare, genetic skin disease that causes skin to blister and scrape off with the slightest friction or trauma. It affects the skin and lining of the mouth and esophagus. Previously, there was no treatment and no chance for cure.
In some countries, even euthanasia has been considered for newborns with the severest forms. If children with EB do not die of infection in their early life, many with the disease do not live beyond their 20s or 30s because they develop an aggressive form of skin cancer. While a few will live long term, the severest forms of EB are generally lethal.
"Bone marrow transplantation is one of the riskiest procedures in medicine, yet it is also one of the most successful. Patients who otherwise would have died from their disease can often now be cured. It''s a serious treatment for a serious disease," said Tolar. (ANI)
Equal survival rates between two major sources of blood cells.
Interesting news...
Patients who receive a blood stem cell transplant from a donor outside of their family to treatleukemia and other blood diseases are more likely to have graft failure but less likely to experience graft-versus-host disease, a condition caused by the donor cells attacking the recipient’s body, if the transplanted blood cells come directly from a donor’s bone marrow, rather than from blood stem cells circulating in the donor’s bloodstream (PBSCs), according to new research. Although the study showed differences in the type and extent of complications, the results showed no difference in patient survival rates between these two major sources of donated blood cells.
Patients who receive a blood stem cell transplant from a donor outside of their family to treatleukemia and other blood diseases are more likely to have graft failure but less likely to experience graft-versus-host disease, a condition caused by the donor cells attacking the recipient’s body, if the transplanted blood cells come directly from a donor’s bone marrow, rather than from blood stem cells circulating in the donor’s bloodstream (PBSCs), according to new research. Although the study showed differences in the type and extent of complications, the results showed no difference in patient survival rates between these two major sources of donated blood cells.
Another one doubt...
High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT), for previously untreated patients with advanced follicular lymphoma (FL) does not improve overall survival compared with conventional-dose chemotherapy alone, according to an online study published December 21 in the Journal of the National Cancer Institute.
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